32 стр.
Формат файла
.rtf — Rich Text Format (Wordpad)
107470.zip — 431.51 kb
  • the-role-of-deuterium-in-molecular-evolution_107470_1.rtf — 1503.34 Kb
  • Readme_docus.me.txt — 125 Bytes
Оцените работу
Хорошо  или  Плохо

Текст работы

discuss the matter, we should distingueshed mainly three aspects of biological enrichment with deuterium: chemical, biological and biophysical aspects, all of them are connected in some way with the structure of [U 2
H]labeled macromolecules. Theoretically, the presence of deuterium in biological systems certainly could be manifested in more or less degree by changes in the structure and the conformation of macromolecules. Nevertheless, it is important namely what precise position in macromolecule deuterium ocupied and dipending from that the primary and secondary isotopic effects are distingueshied. For example, most important for the structure of macromolecule the hydrogen (deuterium) bonds form between different parts of the macromolecule and play a major part in determining the structure of macromolecular chains and how these structures interact with the others and also with
2 H 2 O environment
. Another important weak force is created by the three-dimentional structure of water ( 2 H 2
O), which tends to force hydrophobic groups of macromolecule together in order to minimize their disruptive effect on the hydrogen (deuterium)-bonded network of water ( 2
H 2 O) molecules.
On the other side the screw parameters of the proton helix are changed by the presence of deuterium so that ordinary proteins dissolved in 2 H
2 O exhibit a more stable helical structure ( Tomita K., Rich A., et all., 1962 ). While
2 H 2 O probably exerts a stabilizing effect upon the three-dimentional hydrogen (deuterium)-bonded helix via
forming many permanent and easily exchangeable hydrogen (deuterium) bonds in macromolecule in the presence of 2 H 2
O (as an example the following types of bonds -COO 2 H; -O 2
H; -S 2 H; -N 2 H; N

Ваше мнение