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of 2
H 2 O (99% 2
H), which since yet resulted in a miscellany of rather confusing data (see as an example Katz J., Crespy H. L. 1972 ).
The main resolute conclusion that can be derived from the most competent and comprehensive of the early studies is that high concentrationsof 2 H
2 O are incompatible with life and reproduction and furthemore could even causing even lethal effects on a cell. However, today a many cells could be adapted to
2 H 2 O either via
employing a special methods of adaptation which of them we shall describe above, or using selected (or/and resistent to 2 H
2 O) strains of bacterial and other origin.
In this connection the main interesting question arises-what is the nature of this interesting phenomenon of biological adaptation to 2 H
2 O and what is the role
of life important macromolecules (particularly DNA, individual proteins, and/or enzymes) in this process? It is seems very likely, that during adaptation to 2 H
2 O the structure and conformation of [U - 2
H]labeled macromolecules undergoing some modifications that are more useful for the working in 2 H 2
O-conditions. Unfortunately, there are a small number of experiments carried out with fully deuterated cells, that could confirmed that during the growth on 2
H 2 O [U- 2
H]labeled macromolecules with difined isotopical structures and conformations are formed, so that a discussion about the role of deuterium on the structure and the conformation of [U- 2
H]labeled macromolecules in course of biolodical adaptation to 2 H 2
O is still actual through more than four decades of years after the first description of the biological consequences of hydrogen replacement by deuterium.
To further

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