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NIZNHNY  NOVGOROD  UNIVERSITY

DEPARTMENT OF ECOLOGY

Summary

HUMANEAPPROCHES

TOTOXICOLOGICAL EVALUATIONS

OFINDUSTRIAL CHEMICALS

Made byLoginov V. V.

  Scientific advisor

d. b. s.,prof. Gelashvili D. B.

NIZHNY  NOVGOROD, 1999

Thereare millions of chemical substances recorded in the scientific literature withmany more being added annually through the endeavors of chemists in industryand academia (Tаble 1). Tens of thousands of these substances are used incommerce, as demonstrated by the publication of inventories in the EuropeanEconomic Community under the Sixth Amendment to the Dangerous SubstancesDirective and in the United States through the Toxic Substances Control Act(TSCA).

Theenormous growth of the chemical industry, coupled with the potential forincreased exposure of the population to chemicala, has generated growing publicconcern and an awareness of the need for correct safety aascsfunent. Thetoxicological assessment, therefore, of the potential health hazards posed bychemical substances to which humans and animals may be directly or indirectlyexposed Is a rational requirement of civilized society.

TABLE 1ChemicalSubstances Known

Group

Approximate number

Documened chemicals

(Chemical Abctracts)

7,000,000

Increase per annum

400,000

EINECS (European Inventory of Existing

Commerical Chemical Substances)

95,000

ECOIN (European Core Inventory)

34,000

Known drugs

4,000

Known pesticides

1.500



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