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NIZNHNY   NOVGOROD 

UNIVERSITY

DEPARTMENT OF ECOLOGY



Summary

HUMANE APPROCHES

TO TOXICOLOGICAL EVALUATIONS

OF INDUSTRIAL CHEMICALS



Made by Loginov V. V.

  Scientific advisor

d. b. s., prof. Gelashvili D.

B.



NIZHNY  NOVGOROD, 1999

There are millions

of chemical substances recorded in the scientific literature with many more

being added annually through the endeavors of chemists in industry and academia

(Tаble 1). Tens of thousands of these substances are used in commerce, as demonstrated

by the publication of inventories in the European Economic Community under the

Sixth Amendment to the Dangerous Substances Directive and in the United States

through the Toxic Substances Control Act (TSCA).

The enormous growth

of the chemical industry, coupled with the potential for increased exposure of

the population to chemicala, has generated growing public concern and an

awareness of the need for correct safety aascsfunent. The toxicological

assessment, therefore, of the potential health hazards posed by chemical

substances to which humans and animals may be directly or indirectly exposed Is

a rational requirement of civilized society.


TABLE 1 Chemical Substances Known

Group

Approximate number

Documened chemicals

(
Chemical Abctracts)

7,000,000

Increase per annum

400,000

EINECS (European Inventory of

Existing

Commerical Chemical Substances)

95,000

ECOIN (European Core Inventory)

34,000

Known drugs

4,000

Known pesticides

1.500




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